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Test Code VITD Vitamin D 25 Hydroxy Level

Important Note

Medicare frequency limitations exist for this test in addition to diagnosis requirements. Click on link for list of medically necessary diagnoses: http://www.munsonhealthcare.org/medical-necessity. Click on link for Advance Beneficiary Notice of Noncoverage form: Advance Beneficiary Notice of Noncoverage

Specimen Requirements

Preparation of Patient: 

None

 

Container Type: 

Gold Top SST Gel & Clot Activator Tube

Specimen Type:

Serum

 

Specimen Volume: 

2.5 mL of Serum minimum 1.0 mL of Serum

 

Specimen Handling/Transport:

Separate serum from cells within 2 hours of collection.

Transport refrigerated 2-8°C.

 

Specimen Stability/Storage:

8 hours ambient room temperature

5 days refrigerated 2-8°C

 

Specimen Rejection:

Moderate hemolysis

Performing Laboratory

Munson Medical Center Laboratories

Priority, Frequency, & Turnaround

Priority:

Non-Emergent

 

Frequency:

24 hours 7 days a week

 

Turnaround:

0 - 1 days

Methodology

Chemiluminescent Immunoassay

Reporting

Reference Range: 

30 - 80 ng/mL

 

Linearity Range:

7 - 120 ng/mL

 

Critical Decision: 

None

 

Result Interpretation:

The National Osteoporosis Foundation has set the following guidelines for 25-OH Vitamin D:

      < 30 ng/mL: Less than desirable

      ≥ 30 - 80 ng/mL: Desirable

      > 80 ng/mL: Above desirable

Clinical Significance

Vitamin D is a steroid hormone involved in the intestinal absorption of calcium and the regulation of calcium homeostasis. Vitamin D is essential for the formation and maintenance of strong, healthy bones. Vitamin D deficiency can result from inadequate exposure to the sun, inadequate alimentary intake, decreased absorption, abnormal metabolism, or vitamin D resistance.1 Recently, many chronic diseases such as cancer,2,3,4 high blood pressure,5 osteoporosis,6,7 and several autoimmune diseases9,10 have been linked to vitamin D deficiency. Whether consumed or produced, both forms of vitamin D (D2 and D3) are metabolized by the liver to 25(OH)D, and then converted in the liver or kidney into 1,25-dihydroxyvitamin D.11 Vitamin D metabolites are bound to a carrier protein in the plasma and distributed throughout the body. The most reliable clinical indicator of vitamin D status is 25(OH)D because serum and plasma 25(OH)D levels reflect the body’s storage levels of vitamin D, and 25(OH)D correlates with the clinical symptoms of vitamin deficiency.

CPT Code

82306