Home
HelpTest Code RENIN Renin Direct
EHR Test Codes
| Test Code | Test Name | |
| Atlas | RENIN | Renin Direct |
| Cerner | Renin Direct |
Specimen Requirements
Preparation of Patient:
Fasting recommended but not required. Draw patient in mid morning, after patient bas been upright and out of bed for > 2 hours. Have patient seated 5 - 10 minutes before collection.
Container Type:
6mL EDTA Lavender Top Tube
Specimen Type:
Plasma
Specimen Volume:
3.0 mL Plasma minimum 1.0 mL
Specimen Handling/Transport:
Keep sample at room temperature and transport immediately to laboratory for processing.
Centrifuge in a non-refrigerated centrifuge. Exposing samples to cold temperature (4°C or below) will activate pro-renin and will falsely elevate results.
For non-MMC hospital laboratories freeze plasma immediately and transport plasma aliquot frozen.
Specimen Stability/Storage:
5 days frozen
Specimen Rejection:
Reject for any hemolysis
Reject if sample has been exposed to cold temperatures (4°C or below) at any point before the sample is frozen.
Performing Laboratory
Munson Medical Center
Chemistry Department
Priority, Frequency, & Turnaround
Priority:
Non-Emergent
Frequency:
Monday, Thursday
Turnaround:
0 - 4 days
Methodology
Chemiluminescence immunoassay (CLIA)
Reporting
Reference Range:
0 years to 40 years 4.2 - 52.2 pg/mL
40 years and up 3.6 - 81.6 pg/mL
Critical Decision:
None
Clinical Significance
The renin-angiotensin-aldosterone system (RAAS) plays a paramount role in water homeostasis and electrolyte balance, and in the regulation of arterial pressure. Measurement of plasma renin and aldosterone is therefore considered a marker of the renin-angiotensin-aldosterone system activity. Measurement of total renin (prorenin plus active renin) or of prorenin have less clinical interest.
Increased renin levels are found in the following conditions; secondary aldosteronism, Addison's disease, Low-sodium diet, administration of diuretics, hemorrhage, chronic renal failure, salt-losing status because of gastrointestinal disease, renin-producing kidney tumors, essential hypertension, hypokalemia, Bartter's syndrome, renal artery stenosis.
Lower renin levels are found in the following conditions; Primary aldosteronism, salt-retaining steroid therapy, Vasopressin therapy, congenital adrenal hyperplasia with 17-hydroxylase deficiency.
CPT Code(s)
84244