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Test Code RENIN Renin Direct

Important Note

Testing at Munson Medical Laboratories coming soon!  Order Mayo sendout test PRA Renin Activity, Plasma. PRA - Overview: Renin Activity, Plasma

 

Direct patients to a hospital outpatient laboratory for collection.  Testing should be ordered with Aldosterone.

EHR Test Codes

  Test Code Test Name
Atlas RENIN Renin Direct Plasma
Cerner   Renin Direct

 

Specimen Requirements

Preparation of Patient: 

Fasting recommended but not required.   Draw patient in mid morning, after patient bas been upright and out of bed for > 2 hours.  Have patient seated 5 - 10 minutes before collection.

 

Container Type: 

6mL EDTA Lavender Top Tube

Specimen Type:

Plasma

 

Specimen Volume: 

3.0 mL Plasma minimum 1.0 mL

 

Specimen Handling/Transport:

Keep sample at room temperature and transport immediately to laboratory for processing.

 

Centrifuge in a non-refrigerated centrifuge.  Exposing samples to cold temperature (4°C or below) will activate pro-renin and will falsely elevate results. 

 

For non-MMC hospital laboratories freeze plasma immediately and transport plasma aliquot frozen.

 

Specimen Stability/Storage:

5 days frozen

 

Specimen Rejection:

Reject for any hemolysis

Reject if sample has been exposed to cold temperatures (4°C or below) at any point before the sample is frozen.

Performing Laboratory

Munson Medical Center

Chemistry Department

Priority, Frequency, & Turnaround

Priority:

Non-Emergent

 

Frequency:

Monday, Thursday

 

Turnaround:

0 - 4 days

Methodology

Chemiluminescence immunoassay (CLIA)

Reporting

Reference Range:

0 years to 40 years 4.2 - 52.2 pg/mL

40 years and up 3.6 - 81.6 pg/mL 

 

Critical Decision: 

 None

Clinical Significance

The renin-angiotensin-aldosterone system (RAAS) plays a paramount role in water homeostasis and electrolyte balance, and in the regulation of arterial pressure. Measurement of plasma renin and aldosterone is therefore considered a marker of the renin-angiotensin-aldosterone system activity. Measurement of total renin (prorenin plus active renin) or of prorenin have less clinical interest.

 

Increased renin levels are found in the following conditions; secondary aldosteronism, Addison's disease, Low-sodium diet, administration of diuretics, hemorrhage, chronic renal failure, salt-losing status because of gastrointestinal disease, renin-producing kidney tumors, essential hypertension, hypokalemia, Bartter's syndrome, renal artery stenosis.

 

Lower renin levels are found in the following conditions; Primary aldosteronism, salt-retaining steroid therapy, Vasopressin therapy, congenital adrenal hyperplasia with 17-hydroxylase deficiency.

CPT Code(s)

84244

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