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Test Code MEX Mexiletine, Serum


Specimen Required


Patient Preparation: Samples should only be collected after patient has been receiving mexiletine for at least 3 days. Trough concentrations should be collected just before administration of the next dose.

Collection Container/Tube: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1.5 mL

Collection Instructions:

1. Samples should only be collected after patient has been receiving mexiletine for at least 3 days.

2. Draw blood immediately before next scheduled dose.

3. Centrifuge within 2 hours of draw and aliquot to remove serum from spun RBCs.


Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.

Useful For

Assessing achievement of optimal therapeutic concentrations

 

Assessing potential toxicity

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Mexiletine, S

Specimen Type

Serum Red

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reject Due To

Gross hemolysis OK
Gross lipemia Reject
Gross icterus OK
 

Reference Values

Trough Value

0.5-2.0 mcg/mL: Therapeutic concentration

>2.0 mcg/mL: Toxic concentration

Day(s) and Time(s) Performed

Monday through Saturday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

80299

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MEX Mexiletine, S 40779-1

 

Result ID Test Result Name Result LOINC Value
9245 Mexiletine, S 40779-1