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Test Name HCVD Hepatitis C Antibody IgG

Additional Codes

Reflex Testing: Specimens with  positive, weakly positive, or equivocal antibody results automatically reflex to a Hepatitis C Quantitative performed at Munson Medical Center.

Specimen Requirements

Preparation of Patient: 

None

 

Container Type: 

Gold Top SST Gel & Clot Activator Tube

Specimen Type:

Serum

 

Specimen Volume: 

2.5 mL of Serum minimum 1.0 mL of Serum

 

Specimen Handling/Transport:

Separate serum from cells within 2 hours of collection.

Transport refrigerated 2-8°C.

 

Specimen Stability/Storage:

4 days ambient room temperature

5 days refrigerated 2-8°C

 

Specimen Rejection:

Gross hemolysis

Gross lipemia

Performing Laboratory

Munson Medical Center Laboratories

Priority, Frequency, & Turnaround

Priority:

Non-Emergent

 

Frequency:

Monday through Friday

 

Turnaround:

0-3 Days

Methodology

Indirect Chemiluminometric Immunoassay (CLIA)

Reporting

Reference Range:

Negative

 

Critical Decision:

None

 

Result Interpretation:

Reported as S/CO (signal to cut-off ratio) with a cut-off of 1.0

  • S/CO <0.80 are considered NEGATIVE
  • S/CO ≥1.0 are considered POSITIVE
  • S/CO ≥0.80 and <1.0 are considered EQUIVOCAL and must be repeated in duplicate.  If 2/3 results are <1.0, the test is NEGATIVE.  If 2/3 are ≥1.0 the test is POSITIVE

CPT Code(s)

86803

G0472

Clinical Significance

Hepatitis C virus (HCV) was identified in 1988 as a single-stranded positive-sense RNA virus, globally distributed.  Patients infected with HCV are generally asymptomatic during the acute stage of the disease, however, the small proportion of people who get sick during the acute infection may exhibit symptom such as jaundice, pain in the upper right part of the abdomen, and nausea for up to 12 weeks. Testing people with known risk factors is recommended by both the WHO and the CDC. Approximately 70 - 80% of infected individuals develop chronic hepatitis and, may eventually, acquire liver cirrhosis and hepatocellular carcinoma. Liver disease associated with chronic HCV infection is the leading cause of hepatocellular carcinoma and liver transplantation in the United States

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