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Test Code FIB Fibrinogen Level

EHR Test Codes

  Test Code Test Name
Atlas FIB Fibrinogen
Cerner   Fibrinogen Level

 

Specimen Requirements

Preparation of Patient: 

None

 

Container Type:

Light Blue Top 3.2% Sodium Citrate Tube 4.5 mL, 3.0 mL, 2.7 mL, 2.0 mL, or 1.8 mL

Specimen Type:

Plasma platelet poor

 

Specimen Volume:

Fill tube completely.  Less than 90% filled tubes will be rejected.

 

Special Instructions:

For patients who are difficult access, < 1 year, and/or have a hematocrit > 55.9%; special tubes with an adjusted amount of anticoagulant can be prepared to allow for proper blood/anticoagulant ratio for accurate testing.  Call the Hematology lab at 231-935-6118 to request special tube.

 

Specimen Handling/Transport:

Do not centrifuge.  Do not refrigerate.  Deliver to laboratory immediately.

Transport ambient room temperature.

 

Special Instructions

If a specimen cannot be tested within 8 hours of draw, plasma should be removed from the cells and preserved as follows: Spin in a centrifuge verified for platelet-poor plasma preparation, remove plasma to a plastic tube, spin the plasma a second time, then remove plasma to a screw-top plastic  tube and freeze immediately at -20° C. Transport frozen.

 

Specimen Storage/Stability:

Whole blood ambient room temperature 8 hours. 

Double spun plasma aliquot ambient room temperature 24 hours.

Double spun plasma aliquot frozen -20° C 4 months.

 

Specimen Rejection:

Less than 90% filled tubes

Hemolysis

Clotted

Performing Laboratory

Munson Healthcare Laboratories

Priority, Frequency, & Turnaround

Priority:

STAT, ASAP, Non-Emergent

 

Frequency:

24 hours 7 days a week

 

Turnaround:

0 - 1 days

STAT 60 minute from receipt in lab

Methodology

Electromagnetic Mechanical Clot Detection System

Reporting

Reference Range:

177 - 493 mg/dL

 

Critical Decision: 

≤ 100 mg/dL

Note:  Critical values are called to the provider and communicated as critical.  Documentation of the call is recorded in the patient record.

Clinical Significance

Fibrinogen is synthesized in the liver and by megakaryocytes. It is composed of six chains: 2 A alpha, 2 B beta and 2 gamma. Thrombin (factor IIa) breaks up the fibrinogen molecule to split out 2 fibrinopeptide A (FPA) fragments from the A alpha chains and 2 fibrinopeptide B (FPB) fragments from the B chains. The fibrin monomers that are produced from these reactions then aggregate to form fibrin, which is subsequently stabilized by factor XIIIa. The first step of this stabilization consists of the binding of two chains of two fibrin monomers. This binding is the origin of D-dimer, the degradation product that is specific of fibrin. Fibrinogen can be degraded by plasmin. An increase of fibrinogen level is found in cases of diabetes, inflammatory syndromes, obesity; a decrease of the fibrinogen level is observed in DIC, fibrinogenolysis. Furthermore, fibrinogen seems to be involved in the pathogenicity of thrombotic cardiovascular events.

CPT Code(s)

85384