Test Code FIB Fibrinogen Level
EHR Test Codes
| Test Code | Test Name | |
| Atlas | FIB | Fibrinogen |
| Cerner | Fibrinogen Level |
Specimen Requirements
Preparation of Patient:
None
Container Type:
Light Blue Top 3.2% Sodium Citrate Tube 4.5 mL, 3.0 mL, 2.7 mL, 2.0 mL, or 1.8 mL
Specimen Type:
Plasma platelet poor
Specimen Volume:
Fill tube completely. Less than 90% filled tubes will be rejected.
Special Instructions:
For patients who are difficult access, < 1 year, and/or have a hematocrit > 55.9%; special tubes with an adjusted amount of anticoagulant can be prepared to allow for proper blood/anticoagulant ratio for accurate testing. Call the Hematology lab at 231-935-6118 to request special tube.
Specimen Handling/Transport:
Do not centrifuge. Do not refrigerate. Deliver to laboratory immediately.
Transport ambient room temperature.
Special Instructions:
If a specimen cannot be tested within 8 hours of draw, plasma should be removed from the cells and preserved as follows: Spin in a centrifuge verified for platelet-poor plasma preparation, remove plasma to a plastic tube, spin the plasma a second time, then remove plasma to a screw-top plastic tube and freeze immediately at -20° C. Transport frozen.
Specimen Storage/Stability:
Whole blood ambient room temperature 8 hours.
Double spun plasma aliquot ambient room temperature 24 hours.
Double spun plasma aliquot frozen -20° C 4 months.
Specimen Rejection:
Less than 90% filled tubes
Hemolysis
Clotted
Performing Laboratory
Munson Healthcare Laboratories
Priority, Frequency, & Turnaround
Priority:
STAT, ASAP, Non-Emergent
Frequency:
24 hours 7 days a week
Turnaround:
0 - 1 days
STAT 60 minute from receipt in lab
Methodology
Electromagnetic Mechanical Clot Detection System
Reporting
Reference Range:
177 - 493 mg/dL
Critical Decision:
≤ 100 mg/dL
Note: Critical values are called to the provider and communicated as critical. Documentation of the call is recorded in the patient record.
Clinical Significance
Fibrinogen is synthesized in the liver and by megakaryocytes. It is composed of six chains: 2 A alpha, 2 B beta and 2 gamma. Thrombin (factor IIa) breaks up the fibrinogen molecule to split out 2 fibrinopeptide A (FPA) fragments from the A alpha chains and 2 fibrinopeptide B (FPB) fragments from the B chains. The fibrin monomers that are produced from these reactions then aggregate to form fibrin, which is subsequently stabilized by factor XIIIa. The first step of this stabilization consists of the binding of two chains of two fibrin monomers. This binding is the origin of D-dimer, the degradation product that is specific of fibrin. Fibrinogen can be degraded by plasmin. An increase of fibrinogen level is found in cases of diabetes, inflammatory syndromes, obesity; a decrease of the fibrinogen level is observed in DIC, fibrinogenolysis. Furthermore, fibrinogen seems to be involved in the pathogenicity of thrombotic cardiovascular events.
CPT Code(s)
85384