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Test Code ATTF Antithrombin Activity, Plasma

Reporting Name

Antithrombin Activity, P

Useful For

Diagnosis of antithrombin deficiency, acquired or congenital

 

Monitoring treatment of antithrombin deficiency disorders, including infusion of antithrombin therapeutic concentrate

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Plasma Na Cit


Advisory Information


Coagulation testing is highly complex, often requiring the performance of multiple assays and correlation with clinical information. For that reason, we suggest ordering AATHR / Thrombophilia Profile, Plasma.



Specimen Required


See Coagulation Studies in Special Instructions: Guidelines for Specimen Handling and Processing.

 

Specimen Type: Platelet-poor plasma

Collection Container/Tube: Light-blue top (citrate)

Submission Container/Tube: Polypropylene vial

Specimen Volume: 1 mL

Collection Instructions:

1. Centrifuge, remove plasma, and centrifuge plasma again.

2. Freeze plasma immediately (no longer than 4 hours after collection) at -20° C, or, ideally ≤ -40° C.

Additional Information:

1. Double-centrifuged specimen is critical for accurate results as platelet contamination may cause spurious results.

2. Each coagulation assay requested should have its own vial.

3. Heparin treatment may lower plasma antithrombin.


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Na Cit Frozen 14 days

Special Instructions

Reference Values

≥6 months-adults: 80-130%

Normal, full-term newborn infants may have decreased levels (≥35-40%), which reach adult levels by 90 days postnatal.*

Healthy, premature infants (30-36 weeks gestation) may have decreased levels which reach adult levels by 180 days postnatal.*

 

*See Pediatric Hemostasis References in Coagulation Studies in Special Instructions.

Day(s) and Time(s) Performed

Monday through Friday

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

85300

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ATTF Antithrombin Activity, P 27811-9

 

Result ID Test Result Name Result LOINC Value
ATTF Antithrombin Activity, P 27811-9

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Method Name

Chromogenic Assay