Sign in →

Test Code APIXA Apixaban, Anti-Xa, Plasma


Advisory Information


This assay is not indicated for monitoring low-molecular-weight heparin (LMWH) or unfractionated heparin (UFH) concentrations. The presence of UFH and LMWH will cause the apixaban anti-Xa level to be falsely elevated.



Necessary Information


If priority specimen, mark request form, give reason, and request a call-back.



Specimen Required


See Coagulation Studies in Special Instructions: Guidelines for Specimen Handling and Processing.

 

Specimen Type: Platelet-poor plasma

Collection Container/Tube: Light-blue top (citrate)

Submission Container/Tube: Polypropylene vial

Specimen Volume: 1 mL

Collection Instructions:

1. Specimen should be drawn 2 to 4 hours (peak) after a dose or just prior (trough) to the next dose for apixaban concentrations.

2. Spin down, remove plasma, and spin plasma again.

3. Freeze plasma immediately (no longer than 4 hours after collection) at -20° C, or, ideally ≤ -40° C.

Additional Information:

1. A double-centrifuged specimen is critical for accurate results as platelet contamination may cause spurious results.

2. Each coagulation assay requested should have its own vial.


Useful For

Measuring apixaban concentration in selected clinical situations (eg, renal insufficiency, assessment of compliance, periprocedural measurement of drug concentration, suspected overdose, advanced age and extremes of body weight)

Special Instructions

Method Name

Chromogenic Assay

Reporting Name

Apixaban, Anti-Xa, P

Specimen Type

Plasma Na Cit

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Na Cit Frozen 14 days

Reject Due To

All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Reference Values

<10 ng/mL

Day(s) and Time(s) Performed

Monday through Friday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

80299

LOINC Code Information

Test ID Test Order Name Order LOINC Value
APIXA Apixaban, Anti-Xa, P 74214-8

 

Result ID Test Result Name Result LOINC Value
APIX1 Apixaban, Anti-Xa, P 74214-8
APIX2 Interpretation 69049-5
APIX3 Cautions 62364-5