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Test Code APGH Alpha-Subunit Pituitary Tumor Marker, Serum

Specimen Required

Collection Container/Tube: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL


If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.

Useful For

Adjunct in the diagnosis of pituitary tumors


As part of the follow-up of treated pituitary tumor patients


Differential diagnosis of thyrotropin-secreting pituitary tumor versus thyroid hormone resistance


Differential diagnosis of constitutional delay of puberty versus hypogonadotrophic hypogonadism

Method Name

Immunochemiluminescent Assay

Reporting Name

AlphaSubunit Pituitary Tumor Marker

Specimen Type

Serum Red

Specimen Minimum Volume

0.35 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Frozen (preferred) 90 days
  Refrigerated  7 days

Reject Due To

Gross hemolysis Reject
Gross lipemia OK
Gross icterus OK

Reference Values


≤5 days: ≤50 ng/mL

6 days-12 weeks: ≤10 ng/mL

3 months-17 years: ≤1.2 ng/mL

Tanner II-IV*: ≤1.2 ng/mL



Males: ≤0.5 ng/mL

Premenopausal females: ≤1.2 ng/mL

Postmenopausal females: ≤1.8 ng/mL


Pediatric and adult reference values based on Mayo studies.


*Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for boys at a median age of 11.5 (±2) years and for girls at a median age of 10.5 (±2) years. There is evidence that it may occur up to 1 year earlier in obese girls and in African American girls. For boys, there is no proven relationship between puberty onset and body weight or ethnic origin. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.

Day(s) and Time(s) Performed

Wednesday; 10 a.m.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
APGH AlphaSubunit Pituitary Tumor Marker 14170-5


Result ID Test Result Name Result LOINC Value
9003 AlphaSubunit Pituitary Tumor Marker 14170-5