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Test Code MPSS Monoclonal Protein Study, Serum

Reporting Name

Monoclonal Protein Study, S

Useful For

Diagnosis of monoclonal gammopathies, when used in conjunction with urine monoclonal studies

 

Monitoring patients with monoclonal gammopathies

 

Protein electrophoresis alone is not considered an adequate screen for monoclonal gammopathies

Profile Information

Test ID Reporting Name Available Separately Always Performed
TPE Total Protein Yes, (order TP) Yes
ELP Protein Electrophoresis No Yes
IMFX Immunofixation Yes, (order IMFXO) Yes

Testing Algorithm

This test includes total protein, serum protein electrophoresis, and heavy and light chain typing (kappa and lambda).

 

The following algorithms are available in Special Instructions:

-Laboratory Approach to the Diagnosis of Amyloidosis

-Laboratory Screening Tests for Suspected Multiple Myeloma

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum


Advisory Information


To monitor a patient with an established diagnosis of a monoclonal gammopathy, order MMOGA / Monoclonal Gammopathy Monitoring, Serum.



Specimen Required


Patient Preparation: Fasting preferred but not required

Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 1 mL


Specimen Minimum Volume

0.6 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Ambient  14 days
  Frozen  14 days

Reference Values

PROTEIN, TOTAL

≥1 year: 6.3-7.9 g/dL

Reference values have not been established for patients that are <12 months of age.

 

PROTEIN ELECTROPHORESIS

Albumin: 3.4-4.7 g/dL

Alpha-1-globulin: 0.1-0.3 g/dL

Alpha-2-globulin: 0.6-1.0 g/dL

Beta-globulin: 0.7-1.2 g/dL

Gamma-globulin: 0.6-1.6 g/dL

An interpretive comment is provided with the report.

Reference values have not been established for patients that are <16 years of age.

 

IMMUNOFIXATION

No monoclonal protein detected

Day(s) and Time(s) Performed

Monday through Saturday; 2 p.m.

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

84155

84165

86334

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MPSS Monoclonal Protein Study, S 24351-9

 

Result ID Test Result Name Result LOINC Value
81653 Immunofixation 74665-1
TPE Total Protein 2885-2
2769 Albumin 2862-1
2770 Alpha-1 Globulin 2865-4
2771 Alpha-2 Globulin 2868-8
2773 Beta-Globulin 2871-2
2774 Gamma-Globulin 2874-6
2785 A/G Ratio 44429-9
22308 M spike 33358-3
22309 M spike 33358-3
15254 Impression 12851-2

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Method Name

TPE: Biuret

ELP: Agarose Gel Electrophoresis

IMFX: Immunofixation

Forms

If not ordering electronically, complete, print, and send a General Request with the specimen.