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Test Code ELYME Lyme Disease European Antibody Screen, Serum

Advisory Information

This test should only be ordered for patients who present with Lyme disease symptoms and who have recently returned from travel to Europe or Asia. These patients may be infected with Lyme disease causing Borrelia species endemic to Europe (eg, B afzelii, B garinii), which may not be detected using diagnostic tests in North America. The North American serologic assays for Lyme disease are developed specifically for detection of antibodies to B burgdorferi (strain B31), the most commonly encountered species.


Patients who are suspected to have Lyme disease who have not traveled to Europe should be tested by the LYME / Lyme Disease Serology, Serum assay for detection of antibodies specifically to Borrelia burgdorferi, the most common agent of Lyme disease in North America.

Specimen Required

Supplies: Aliquot Tube, 5 mL (T465)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: 5-mL aliquot tube (T465)

Specimen Volume: 0.5 mL

Pediatric: 0.5 mL


If not ordering electronically, complete, print, and send a Microbiology Test Request (T244) with the specimen.

Useful For

Aids in diagnosis of Lyme disease caused by infection with Borrelia species endemic to Europe and Asia, including B garinii and B afzelii.


This test is only intended for use in patients with recent travel to and exposure to ticks in Europe or regions of Asia who are suspected to have Lyme disease caused by Borrelia species endemic to Europe/Asia.

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
ELYMI Lyme Disease European Immunoblot, S No No

Testing Algorithm

If this test is positive or equivocal, then immunoblot testing will be performed at an additional charge.


See Acute Tick-Borne Disease Testing Algorithm in Special Instructions.

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)

Reporting Name

Lyme Disease European Ab Screen, S

Specimen Type


Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 10 days
  Frozen  30 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Other Heat-inactivated specimen

Reference Values


Day(s) and Time(s) Performed

Monday through Friday; 10 a.m.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


86617 x 2 - Lyme Disease European Immunoblot, S (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ELYME Lyme Disease European Ab Screen, S 57916-9


Result ID Test Result Name Result LOINC Value
ELYME Lyme Disease European Ab Screen, S 57916-9