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Test Code CAPN Solid Tumor-Targeted Cancer Gene Panel, Next-Generation Sequencing, Varies

Useful For

Identifying solid tumors that may respond to targeted therapies by assessing multiple gene targets simultaneously


Identifying specific variants within genes known to be associated with response or resistance to specific cancer therapies


Identifying variants that may help determine prognosis for patients with solid tumors


Assisting in establishing a diagnosis (eg, KIT and PDGFRA alterations for gastrointestinal stromal tumors)


Aiding in the determination of clinical trial eligibility for patients with genetic variants not amenable to current FDA-approved targeted therapies


This test is not intended for use for hematological malignancies or assessment of germline variants

Additional Tests

Test ID Reporting Name Available Separately Always Performed
SLIRV Slide Review in MG No, (Bill Only) Yes

Testing Algorithm

When this test is ordered, slide review will always be performed at an additional charge.

Method Name

Polymerase Chain Reaction (PCR)-Based Next Generation Sequencing

Reporting Name

Solid Tumor Targeted Cancer Panel

Specimen Type


Advisory Information

At least 20% tumor is required for this assay. The amount of tissue needed is dependent on a variety of preanalytical factors (eg, cellularity, ischemic time, fixation). In general, the minimum specimen adequacy for this test is approximately a 6 mm(2) area of tissue (can be over multiple slides from one tissue block) or 5,000 total cells (5,000 total nucleated cells if using cytology slides).

Necessary Information

Pathology report must accompany specimen in order for testing to be performed.

Specimen Required


Specimen Type: Tissue block

Collection Instructions: Submit a formalin-fixed, paraffin-embedded tissue block.



Specimen Type: Tissue slide

Slides: 1 stained and 10 unstained

Collection Instructions: Submit 1 slide stained with hematoxylin and eosin and 10 unstained, nonbaked slides with 5-micron thick sections of the tumor tissue.



Specimen Type: Cytology slide (direct smears or ThinPrep)

Slides: 1-2 slides (stained and cover slipped) with a minimum of 5,000 total nucleated cells

Collection Instructions: Submit 1-2 slides stained and cover slipped.

Additional Information: Cytology slides will not be returned.

Specimen Minimum Volume

Formalin-fixed, paraffin-embedded (FFPE) tissue block (preferred) or 1 slide stained with hematoxylin and eosin and 8 unstained, non-baked slides with 5-microns thick sections of the tumor tissue with at least 6 mm(2) area of tissue (can be over multiple slides) and 20% tumor nuclei, 1 stained and coverslipped cytology slide with at least 5,000 total nucleated cells and at least 20% tumor cells.

Specimen Stability Information

Specimen Type Temperature Time Special Container
Varies Ambient (preferred)

Reject Due To

Other Specimens that have been decalcified (all methods) Specimens that have not been formalin-fixed, paraffin-embedded

Reference Values

An interpretive report will be provided.

Day(s) and Time(s) Performed

Monday through Friday; Varies

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

81445-Targeted genomic sequence analysis panel, solid organ neoplasm

Slide Review

88381-Microdissection, manual

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CAPN Solid Tumor Targeted Cancer Panel In Process


Result ID Test Result Name Result LOINC Value
52611 Result Summary 50397-9
52612 Result 73977-1
52613 Interpretation 69047-9
52614 Additional Information 48767-8
52615 Specimen 31208-2
52616 Source 31208-2
52617 Tissue ID 80398-1
52618 Released By 18771-6


If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.